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Table 6 Prevalence 1 of groups of BD in Monchegorsk, stratified by time-period

From: Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study

Group of birth defect

73-82

83-92

93-02

03-11

p-value for trend

Congenital malformations of the nervous system

0.8

2.0

2.8

1.9

0.04

(0.2-1.3)

(1.2-2.9)

(1.4-4.2)

(0.7-3.9)

Congenital malformations of eye, ear, face and neck

0.2

0.3

1.1

1.1

0.02

(0–0.5)

(0–0.6)

(0.2-1.9)

(0.2-2.0)

Congenital malformations of the circulatory system

2.4

1.9

2.8

1.3

0.37

(1.4-3.4)

(1.1-2.8)

(1.4-4.2)

(0.3-2.3)

Congenital malformations of the respiratory system

1.3

0.6

1.4

0.6

0.38

(0.6-2.1)

(0.1-1.1)

(0.4-2.4)

(0–1.2)

Cleft lip and cleft palate

1.3

0.7

2.1

1.9

0.46

(0.6-2.1)

(0.2-1.2)

(0.9-3.3)

(0.3-2.3)

Other congenital malformations of the digestive system

1.4

1.3

0.7

1.1

0.37

(0.7-2.2)

(0.6-2.0)

(0–1.4)

(0.2-2.0)

Congenital malformations of genital organs

1.8

4.6

4.9

3.9

0.02

(0.9-2.6)

(3.3-5.9)

(3.1-6.8)

(2.2-5.6)

Congenital malformations of the urinary system

0.2

0.4

4.4

19.1

<0.0001

(0–0.5)

(0–0.8)

(2.7-6.1)

(15.4-22.7)

Congenital malformations and deformations of the musculoskeletal system

8.3

17.3

13.6

10.2

0.39

(6.5-10.2)

(14.8-19.8)

(10.6-16.6)

(7.5-12.9)

Other congenital malformations, excluding multiple

2.4

6.6

1.4

2.2

0.14

(1.4-3.4)

(5.0-8.2)

(0.4-2.4)

(1.0-3.5)

Chromosomal abnormalities, not elsewhere classified

1.0

0.6

0.5

0.7

0.51

(0.3-1.6)

(0.1-1.1)

(0–1.1)

(0–1.5)

Multiple congenital malformation, not classified

2.3

4.2

2.8

3.0

0.71

(1.3-3.3)

(2.9-5.4)

(1.4-4.2)

(1.5-4.4)

  1. 1Newborns with all BD were included in the analysis; per 1000 newborns (LB plus SB), with 95% CI in brackets.