Table 1 The clinical, hormonal and metabolic parameters in patients with PCOS and control women
Variables | PCOS(n = 263) | Control(n = 263) | P-value |
|---|---|---|---|
Age (years) | 26.78 ± 4.95 | 29.02 ± 6.04 | <0.001 |
Waist (cm) | 99.29 ± 13.30 | 93.25 ± 12.05 | <0.001 |
Waist-hip ratio (WHR) | 0.91 ± 0.75 | 0.89 ± 0.69 | <0.001 |
BMI (kg/m2) | 31.08 ± 5.82 | 28.66 ± 5.04 | <0.001 |
Systolic blood pressure (mmHg) | 125.04 ± 11.94 | 123.25 ± 11.28 | 0.078 |
Diastolic blood pressure (mmHg) | 82.21 ± 8.07 | 81.29 ± 7.43 | 0.178 |
AMH (ng/mL) | 5.39 ± 2.02 | 2.49 ± 1.72 | <0.001 |
Total testosterone (ng/mL) | 0.44 ± 0.21 | 0.27 ± 0.13 | <0.001 |
SHBG (nmol/L) | 28.01 ± 22.09 | 41.08 ± 32.39 | <0.001 |
Glucose metabolism profile | |||
Fasting insulin (FI) (μU/ml) | 15.98 ± 10.12 | 10.75 ± 5.62 | <0.001 |
2-h insulin (2-h I) (μU/ml) | 93.79 ± 69.33 | 59.15 ± 39.24 | <0.001 |
Fasting glucose (FG) (mg/dL) | 90.96 ± 16.72 | 90.01 ± 12.30 | 0.458 |
2-h glucose (2-h G)(mg/dL) | 126.44 ± 46.75 | 116.06 ± 28.56 | 0.002 |
QUICKI | 0.37 ± 0.03 | 0.34 ± 0.03 | 0.001 |
Ratio of 2-h glucose to 2-h insulin | 1.96 ± 1.35 | 2.58 ± 1.40 | <0.001 |
Fasting glucose/fasting insulin | 7.74 ± 5.24 | 10.61 ± 5.88 | <0.001 |
HOMA-IR | 3.67 ± 2.683 | 2.41 ± 1.42 | <0.001 |
HOMA-B | 227.99 ± 154.67 | 161.94 ± 105.27 | <0.001 |
Matusda index | 5.21 ± 3.75 | 7.19 ± 4.13 | 0.005 |
Insulin resistance (IR) | 112 (42.6) | 45 (17.1) | <0.001 |
Normal GTT | 176 (66.9) | 196 (74.5) | 0.105 |
Prediabetes (IFG and/or IGT) | 75 (28.5) | 61 (23.2) | |
Type 2 diabetes mellitus | 12 (4.6) | 6 (2.3) | |
Family history of T2DM | 131 (49.8) | 104 (39.5) | 0.022 |
Lipid profile | |||
Total cholesterol (TC) (mg/dL) | 173.30 ± 34.86 | 165.29 ± 32.59 | 0.018 |
Triglycerides (TG) (mg/dL) | 125.73 ± 87.01 | 96.73 ± 57.15 | <0.001 |
HDL (mg/dL) | 43.69 ± 9.68 | 45.22 ± 8.85 | 0.059 |
LDL (mg/dL) | 81.55 ± 23.83 | 77.31 ± 21.87 | 0.034 |
Cardiovascular risk (TG/HDL) | 3.17 ± 3.03 | 2.28 ± 1.61 | <0.001 |
Metabolic syndrome (MetS) | 141 (53.6) | 86 (32.7) | <0.001 |