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Table 3 Distribution of insulin resistance, glucose tolerance, MetS parameters and family history of T2DM among PCOS phenotypes and control

From: A case–control observational study of insulin resistance and metabolic syndrome among the four phenotypes of polycystic ovary syndrome based on Rotterdam criteria

Variables

PCOS (n = 263)

A (n = 139)

B (n = 10)

C (n = 36)

D (n = 78)

Control (n = 263)

P-value PCOS phenotypes vs controls

Fasting insulin ≥20 μU/mL

64 (24.3)

33 (23.7)

4 (40)

10 (27.8)

17(21.8)

17 (6.5)

<0.001

Fasting glucose/Fasting insulin ≤4.5

61 (23.2)

32 (23)

4 (40)

10 (27.8)

15(19.2)

17 (6.5)

< 0.001

HOMA-IR ≥ 3.8

90 (34.2)

49 (35.3)

5 (50)

12 (33.3)

24(30.8)

36 (13.7)

< 0.001

Ratio 2-h glucose/2-h insulin ≤1

61 (23.2)

40 (28.8)

3 (30)

9 (25)

9 (11.5)

13(4.9)

< 0.001

Normal GTT

176 (66.9)

88 (63.3)

5 (50)

26 (72.2)

57(73.1)

196(74.5)

0.092

Prediabetes (IFG and/or IGT)

75 (28.5)

46 (33.1)

5 (50)

8 (22.2)

16(20.5)

61(23.2)

Type 2 diabetes mellitus

12 (4.6)

5 (3.6)

0 (0)

2 (5.6)

5 (6.4)

6 (2.3)

Insulin resistance (IR)

112 (42.6)

64 (46)*

5 (50)*

17(47.2)*

26(33.3)*

45(17.1)

<0.001

Metabolic syndrome (MetS)

141 (53.6)

81 (58.3)**

8(80)**

17(47.2)**

35(44.9)**

86(32.7)

<0.001

Family history of T2DM

131 (49.8)

65 (46.8)+

4 (40)+

18 (50)+

44(56.4)+

104 (39.5)

0.094

  1. Data are shown as n (%). P-values were calculated using Chi-square test.
  2. *Insulin resistance frequencies did not differ significantly between the PCOS phenotypes (P = 0.271).
  3. **Metabolic syndrome frequencies did not differ significantly between phenotypes (P = 0.069).
  4. +Family history of T2DM frequencies did not differ significantly between phenotypes (P = 0.525).
  5. (Note: (i) Phenotype A (O + H + P), (ii) Phenotype B (O + H), (iii) Phenotype C (H + P) and (iv) Phenotype D (O + P). IFG: impaired fasting glucose, IGT: impaired glucose tolerance.