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Table 3 ACT intervention effect on antenatal corticosteroid use and 28-day neonatal mortality by site

From: The Antenatal Corticosteroids Trial (ACT): a secondary analysis to explore site differences in a multi-country trial

Region

South Asia

Sub-Saharan Africa

Latin America

Characteristic

Belgaum, India

Nagpur, India

Pakistan

Zambia

Kenya

Guatemala

Argentina

ACS use among all women %

       

 Intervention clusters

11.3

9.3

23.4

14.4

2.9

9.1

17.2

 Control clusters

1.8

1.3

1.5

0.3

0.4

1.0

9.2

Neonatal mortality <28 daysa, N (Rate/1000)

       

 Neonatal deaths <5th %tile

       

  Intervention clusters

133 (249.5)

109 (305.3)

172 (226.3)

30 (151.5)

45 (191.5)

57 (164.7)

20 (219.8)

  Control clusters

158 (255.7)

84 (329.4)

172 (250.4)

27 (127.4)

27 (142.9)

39 (234.9)

17 (129.8)

 Neonatal deaths All births

       

  Intervention clusters

378 (25.8)

221 (29.8)

359 (48.4)

83 (19.6)

103 (17.6)

130 (22.6)

26 (12.4)

  Control clusters

369 (22.5)

159 (21.3)

397 (49.8)

76 (13.3)

81 (11.5)

102 (26.1)

27 (11.8)

ACT intervention effect on neonatal mortality < 28 daysa [RR (95 % CI)b] for intervention versus control

       

 Neonatal deaths <5th %tile

0.96 (0.75, 1.22)

0.94 (0.72, 1.23)

0.89 (0.80, 0.99)

1.43 (0.90, 2.28)

1.30 (0.94, 1.81)

0.75 (0.69, 0.82)

1.60 (0.99, 2.58)

 Neonatal deaths All births

1.13 (0.99, 1.27)

1.36 (1.09, 1.71)

0.93 (0.82, 1.07)

1.77 (1.42, 2.20)

1.47 (1.02, 2.12)

0.86 (0.72, 1.03)

1.06 (0.54, 2.09)

  1. aThe denominator for neonatal deaths is live births
  2. bHypotheses test results: Relative Risk (RR) with corresponding 95 % CI and p-values calculated from generalized linear models with generalized estimating equations which account for the cluster-level variance and are adjusted for randomization strata