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Table 2 Comparative analysis between children exposed to NNRTI and PI at CAISM/UNICAMP from 2000 to 2015

From: Adverse effects in children exposed to maternal HIV and antiretroviral therapy during pregnancy in Brazil: a cohort study

Variables

NNRTI

PI

p*

RR

CI 95%

n

%

n

%

Gestational age (Capurro)

    

0.2212

  

 <37 weeks

25

17.7

130

22.5

 

0.79

0.53–1.16

 >=37 weeks

116

82.3

449

77.5

 

1

 

Birth weight

    

0.4214

  

 <2500 g

28

19.7

135

22.8

 

0.86

0.59–1.25

 >=2500 g

114

80.3

456

77.2

 

1

 

Weight adequacy for GA

    

0.0051

  

 Adequate for GA

126

89.4

449

77.1

 

1

 

 Small for GA

14

9.9

118

20.3

 

0.48

0.29–0.81

 Large for GA

1

0.7

15

2.6

  

0.04–1.91

5th minute Apgar

    

0.9752

  

 <7

1

0.7

4

0.7

 

1.03

0.18–5.97

 >=7

141

99.3

584

99.3

 

1

 

Neonatal disease

    

0.4002

  

 Yes

33

24.1

160

27.6

 

0.86

0.60–1.23

 No

104

75.9

419

72.4

 

1

 

Birth defect

    

0.5148

  

 Yes

12

8.5

61

10.3

 

0.84

0.49–1.44

 No

130

91.5

533

89.7

 

1

 

Anemia

    

0.0403

  

 Yes

39

32.2

129

23.3

 

1.43

1.02–2.01

 No

82

67.8

424

76.7

 

1

 

Thrombocytopenia

    

0.2841

  

 Yes

2

1.7

22

4

 

0.46

0.12–1.74

 No

119

98.3

532

96

 

1

 

Hepatic changes

    

< 0.0001

  

 Yes

21

80.8

100

31.4

 

7.74

2.99–20.01

 No

5

19.2

218

68.6

 

1

 

TOTAL

142

100

594

100

   
  1. GA gestational age, NNRTI non-nucleoside reverse transcriptase inhibitor, PI protease inhibitor
  2. (#) Numbers are different due to the lack of information on some patients
  3. *Chi-square